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KMID : 1161420200230040388
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Journal of Medicinal Food
2020 Volume.23 No. 4 p.388 ~ p.394
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Effects of Euterpe oleracea to Enhance Learning and Memory in a Conditioned Nicotinic and Muscarinic Receptor Response Paradigm by Modulation of Cholinergic Mechanisms in Rats
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Yildirim Cafer
Aydin Sule
Donertas Basak
Oner Setenay
Kilic Fatma Sultan
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Abstract
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Euterpe oleracea (EO) includes a large number of polyphenolic compounds such as phenolics, flavonoids, and anthocyanins that have antioxidant activities. E. oleracea was suggested to ease the oxidative stress and inflammation in brain cells. Our aim was to analyze the effects of E. oleracea on learning and memory. Seventy-two (250?±?25?g) male Wistar albino rats were used for this study. The groups consisted of control, EO100?mg/kg, EO300?mg/kg, scopolamine 1.5?mg/kg, mecamylamine 7.5?mg/kg, combinations of scopolamine with EO100?mg/kg, EO300?mg/kg, and rivastigmine 1.5?mg/kg; and mecamylamine combined with EO100?mg/kg. Before the start of the study, E. oleracea doses were provided once a day for a period of 15 days and for a 6-day experimental period. Thirty minutes after intraperitoneal scopolamine and mecamylamine injections, gastrogavage was applied to each group. Ninety minutes after the drug treatments, locomotor activity and Morris water maze tests were performed. Rats were killed and each hippocampus was used for the quantification of acetylcholine (Ach). Statistical analyses were calculated using one-way and two-way analyses of variance (ANOVA), and a value of P?
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KEYWORD
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Euterpe oleracea, learning, Morris water maze, rat, spatial memory
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